Dr. Manzi is a medical doctor whose 18-year career spans across emergency medicine; film and television; and health diplomacy.

She currently serves as the Head of Secretariat of the AU COVID-19 Commission and the Head of Secretariat of the Global Leaders Network for Women, Children and Adolescent Health- in these roles supporting H.E. President MC Ramaphosa in his regional and global health leadership roles. She is the lead of Pillar 10 of the Second Presidential Health Compact, which deals with the national agenda for Pandemic Prevention, Preparedness and Response.

She previously held the role of the Spokesperson of the Minister of Health between 2019 and 2021, where she oversaw communication for the introduction of NHI to Parliament and during the COVID-19 pandemic.